
The major themes in the story include the development of new relationships, dealing with grief, love, death, cultural identity, women's roles as mothers and wives, the hardships of life, and the adventures of misunderstandings and coming to terms with reality. At the end of the novel Sal and her grandpa move back to Bybanks. Sal reaches Lewiston, only to find that her mother had died in a bus crash on the way there. Gramps wanted to stay with Gram, but he wanted Salamanca to reach her mother in Lewiston so he gives her his car to drive. Sal reaches Coeur d'Alene while Gram suffers a stroke and has to stay in a hospital. When Sal reaches the Missouri River, her grandmother, or referred to as Gram, is bitten by a Cottonmouth snake. The more she tells her grandparents of Phoebe's story, the more she feels like her story is less connected to Phoebe's story. Throughout the book, as Sal's story unfolds and their car travels west, she reveals more details about Phoebe, and why her story reminds Salamanca of her own. On the trip, Sal entertains her grandparents by telling a story about her friend in Euclid, Ohio, Phoebe Winterbottom, whose mother suddenly disappeared and left their family too, and about Ben Finney, with whom Sal wants to begin a romantic relationship. Sal loves nature and was very close to her mother before she left. Sal's mother has recently left Sal's father, and Sal's grandparents are taking her on a cross-country road trip to Lewiston, Idaho to see her mother. She and her grandparents are from Bybanks, Kentucky, a fictional town based on Quincy, Kentucky, but they are currently renting a house in Euclid, Ohio. The novel is narrated by a 13-year-old girl named Salamanca Hiddle (Sal).

The novel was originally intended as a follow-up to Creech's previous novel Absolutely Normal Chaos but, the idea was changed after she began writing it.

Walk Two Moons is a novel written by Sharon Creech, published by HarperCollins in 1994 and winner of the 1995 Newbery Medal.
